Selenium supplementation associated with reduced colorectal

The April 2006 issue of the International Journal of Cancer published the findings of researchers from Roswell Park Cancer Institute in Buffalo, New York that supplementing with selenium significantly reduced the risk of colorectal adenomas (polyps) among smokers or those whose levels of the mineral were low. Polyps can be a precursor to colorectal cancer (CRC).

The study population consisted of participants in the Nutritional Prevention of Cancer trial follow up who were randomized to receive a 200 microgram per day selenium supplement or a placebo for an average of 7.9 years. Plasma selenium levels, body mass index and smoking status were ascertained upon enrollment. Five hundred ninety-eight subjects received one or more sigmoidoscopic or colonoscopic examinations during the follow up period. There were 99 adenomas found during the initial examinations, which were classified as prevalent, and 61 identified at subsequent examinations, classified as incident. Read more...

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